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Talk by Prof. Dr. Sarah Teichmann in the context of our Distinguished Speaker Series

On Wednesday, April 18, 2012, Prof. Dr. Sarah Teichmann (MRC Laboratory of Molecular Biology, Cambridge, UK) will give a talk in the context of the CBI Distinguished Speaker Series. The talk is entitled "From Protein Interactions To Gene Expression Distributions" and will be held in Room 001, CBI (Building E 2.1) at 17:00 (sharp).

 

Abstract:

The work in my group is focused on the evolution and dynamics of protein interactions and transcriptional regulatory interactions. In these two areas, we analyse large datasets using computational and mathematical methods.
In the first part of my presentation, I will talk about our work on the evolution and assembly of protein complexes. We surveyed three-dimensional structures of protein complexes to identify interface size as a determining principle of both evolutionary and assembly pathways (Levy et al., Nature, 2008), and to quantify conformational change in assembly (Marsh & Teichmann, Structure, 2011). In recent work, we show for the first time, the importance of promiscuous protein interactions in determining a protein’s surface residue composition (Levy et al., in preparation). These new insights have implications for structure prediction and protein engineering.
In the second part of my presentation, I will talk about our work on dissecting the distribution of gene expression levels in mammalian cell populations, revealing two distinct mRNA abundance classes (Hebenstreit et al., Mol Sys Biol, 2011). We provide evidence, including correlation of the two mRNA abundance classes with epigenetic modifications (Hebenstreit et al., Nucleic Acids Res, 2011),supporting the notion that these two classes correspond to functional versus non-functional proteins in cells. These findings now help interpret mRNA and protein abundance data in the form of microarrays, RNA-sequencing and proteomics.