Talk by Prof. Dr. Niko Beerenwinkel in the context of our Distinguished Speaker Series
On Wednesday, February 15, 2017, Prof. Dr. Niko Beerenwinkel (Department of Biosystems Science and Engineering, ETH Zürich, Switzerland) will give a talk in the context of the CBI Distinguished Speaker Series. The talk is entitled "Analyzing virus populations by deep sequencing" and will be held at the Center for Bioinformatics (CBI), building E2 1, lecture room 001, ground floor at 17:00.
RNA viruses can display very high levels of genomic variation within infected individuals. Viral genetic diversity has been associated with disease progression, and the composition of the virus population affects the outcome of antiviral treatment. Deep-coverage next-generation sequencing offers a cost-effective way to probe virus populations, but the resulting error-prone short-read data provides only indirect evidence of the viral quasispecies. We present recent computational approaches to analyzing virus populations by means of deep sequencing, including methods for mutation calling and viral haplotype reconstruction. For HIV, we discuss how to make use of such data for estimating the HIV fitness landscape and for optimizing antiretroviral combination therapies.