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Vortrag von Prof. Dr. Miguel Andrade

Am Mittwoch, 14. juni 2017, wird Prof. Dr. Miguel Andrade einen Vortrag zum Thema "Computational study of protein interaction networks" halten (Raum 001, ZBI (Gebäude E 2.1); Beginn: Punkt 17:00 Uhr).

 

Abstract:

We develop methods and databases to study protein interaction networks. I will present HIPPIE, a database of human protein interactions that are scored according to experimental evidence. Using these data we were able to propose a function of polyQ in the modulation of protein interactions. I will also introduce one of our recent lines of work that regards the study of the topological properties of PPI networks. The topologies of many networks, including the PPI network, can be modelled using hyperbolic geometry, a space whose mathematical properties naturally lead to the emergence of network scale invariance and strong clustering. We will be using such hyperbolic maps for the prediction of links between proteins and to study network evolution.